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or a metabolic precursor, a metabolite or salt thereof, wherein each R, R, R, R, R at the 2, 11 and 15 positions, R10A, R10B, R10C and R10D independently are H, OH, ORPR, SRPR, N RPR, O Si R, CHO, CHS, CN, SCN, NO, ONO, N, NH, COOH, OSO H, OPO H, O, S, NOH, CH, CH CH, N NH C NH N RPR, N NH C NH NH, an ester, a thioester, a thionoester, a phosphoester, a phosphothioester, a phosphonoester, a phosphiniester, a sulfite ester, a sulfate ester, a sulfoxide, a sulfamate, a sulfonate, a sulfamide, a sulfinamide, a sulfurous diamide, an amide, an amino acid, a peptide, an ether, a thioether, an acyl group, a thioacyl group, a carbonate, a carbamate, a halogen, an acetal, a thioacetal a spiro ring, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, an optionally substituted aryl moiety, an optionally substituted heteroaryl moiety, an optionally substituted heterocycle, an optionally substituted monosaccharide, an optionally substituted oligosaccharide, a nucleoside, a nucleotide, an oligonucleotide, a polymer, or, one or more of two adjacent R R, R, R10A, R10B, R10C and R10D are an independently selected epoxide or cyclopropyl ring; R, R and R at the 5 if present, 8, 9 and 14 positions independently are H, CH, C H, OH, ORPR, SRPR, N RPR, O Si R, CHO, CHS, CN, SCN, N, COOH, OS O O OH, an ester, a thioester, a thionoester, a sulfite ester, a sulfate ester, a sulfoxide, a sulfamate, a sulfonate, a sulfamide, a sulfinamide, a sulfurous diamide, an amide, an amino acid, a peptide, an ether, a thioether, an acyl group, a thioacyl group, a carbonate, a carbamate, a halogen, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, an optionally substituted aryl moiety, an optionally substituted heteroaryl moiety, an optionally substituted heterocycle, an optionally substituted monosaccharide, an optionally substituted oligosaccharide, or, one, two or more of R, R and R at the 5, 8, 9 and 14 positions, together with a carbon atom that is adjacent to the carbon to which the R, R or R at the 5, 8, 9 or 14 position is bonded are an independently selected epoxide or cyclopropyl ring; R is C R, C R C R, C R C R C R, C R O C R, C R S C R, C R NRPR C R, O, O C R, S, S C R, NRPR, NH or NRPR C R; R and R independently are C R, C R C R, O, O C R, S, S C R, NRPR or NRPR C R, or one or both of R or R independently are absent, leaving a 5 membered ring; R independently is C alkyl; and RPR independently are H, a protecting group or together are a protecting group, wherein 0, 1, 2, 3 or 4 of R10A, R10B, R10C and R10D are H, R and R respectively are in the ОІ, ОІ, О±, ОІ, ОІ, О± or О±, О± configurations, and wherein, R moieties at the 5 if present, 8, 9 and 14 positions respectively are in the О±, О±, О±, О±, О±, О±, О±, ОІ, О±, О±, ОІ, О±, О±, ОІ, О±, О±, ОІ, О±, О±, О±, О±, О±, ОІ, ОІ, О±, ОІ, О±, ОІ, ОІ, О±, О±, ОІ, ОІ, О±, ОІ, О±, ОІ, ОІ, О±, О±, О±, ОІ, ОІ, О±, О±, ОІ, ОІ, ОІ, ОІ, О±, ОІ, ОІ, ОІ, ОІ, О±, ОІ, ОІ, ОІ, ОІ, О± or ОІ, ОІ, ОІ, ОІ configurations <a>buy cialis online without a prescription</a> PMID 26522218

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